By using 15% polyaorylamide disc gel electrophoresis, nuclear histones of four early developmental stages in silver carp were studied, these four stages are: the late gastrulation; the heart beating; immediately after hatching and the larvae of eye pigmented stages.In these four stages, the core histones(H₄、H_2a、H_2b、H_a) do not show any change.Nevertheless, there are many remarkable changes in number and quantities of H₁ histone in accompany with the degree of cell differentiation, and the historic H₅ which has been discovered in the erythrocytes of some other fishes also appeares in these stages of silver carp likewise.The possible regulating notions of historic H₁ in cell differentiation of the early developmental stages in silver carp were discussed in this paper.