In order to regulate the drug use behavior of aquaculture producers and promote the green development of aquaculture industry in China, based on the survey data of mariculture producers in 11 provinces and cities along the coast of China, this paper used logit model, linear regression model and intermediary effect model to empirically analyze the influence of industrial organization pattern on the drug use behavior of mariculture producers and its mechanism. The results showed that (1) the compact industrial organization had a significant positive effect on the safe drug use behavior of producers; (2) The drug consumption of the producers who joined the compact industry organization decreased significantly; (3) Different types of compact industrial organizations had different influences on the drug use behavior of producers. The "cooperative (association) + producer" mode is significantly better than the "enterprise-led production base + producer" mode. (4) Breeding training had a mediating effect on the influence of compact industrial organization mode on drug use behavior of producers, which could further reduce drug use by training knowledge and skills and providing problem-solving measures. Based on this, the paper puts forward suggestions on attaching importance to the role of compact industrial organizations, especially cooperatives (associations), carrying out training on green aquaculture for producers, and developing aquaculture insurance, so as to accelerate the green development of Chinese aquaculture industry.