The Jifu strain of Nile tilapia Oreochromis niloticus［body weight of (1.29±0.25) g］ were fed with five isonitrigenous (32% protein) and isoenergetic (16 kJ·g-1 gross energy) diets with 0%, 10%, 20%, 30%, 40% cassava meal for 56 days, each treatment was triplicate. The weight gain (WG), feed coefficient (FC), protein efficiency ratio (PER), apparent digestibility (AD) and body composition of tested fish were measured. The cassava meal might improve growth and feed utilization of tested fish. The WG, FC and PER of the fish fed with 40% cassava meal were 1470.99% (P<0.05), 2.36(P<0.05) and 1.27(P<0.05)respectively. The dry matter AD and the protein AD of the fish fed with 40% cassava meal were 79.51% and 94 .83%, which were 13.87% and 7.93% more than those of the control (P<0.05). The lipid AD of the fish fed with 40% cassava meal was 94.73%, which was lower than that of the control (P<0.05). The contents of cru de protein and ash of the fish body in 40% cassava meal group were 7.07% and 8.7 8% higher than those of the control (P<0.05), but the content of its crude lipid was 13.00% lower than that in the control (P<0.05). 30%-40% cassava meal in the diet of tested fish was suggested.