Abalone is one of the important economic shellfish for marine aquaculture. In recent years, under the stress of high temperatures in summer, mass mortality of abalone has often occurred, which has brought huge economic losses to the aquaculture industry. This paper reviews the events of mass mortality of farmed abalone in recent years and summarizes the research progress on the response mechanism of abalone to high-temperature stress abalone from the perspectives of physio-biochemical indicators including growth, reproduction, survival, metabolism and enzyme activity as well as, cellular immunity, antioxidant system, heat shock protein, apoptosis, NF-κB signaling pathway, PI3K-AKT signaling pathway and other related genes expression, DNA methylation, genetic diversity, etc. summarized the research progress of the response mechanism of abalone to high-temperature stress. Existing studies have shown that high temperature stress can cause abnormal physiological and biochemical in abalone to reduce metabolic levels such as feeding, destroy the stability of abalone's internal environment, reduce abalone's ability to resist pathogen invasion and respond to external environmental stimuli, thereby adversely affecting abalone's growth and immunity, which eventually lead to the death of stressed abalone. In order to provide a reference for understanding the response mechanism of abalone to high-temperature stress, facilitate the investigation of the breeding of high-temperature-resistant varieties of abalone and preventing the occurrence of mass mortality of abalone in summer.