Aquaculture of abalone has become an important part of China's marine economic development. In recent years, mass mortality events of farmed abalone caused by hypoxia stress, that combined with hypoxia, had often occurred, which had brought serious economic losses to the abalone aquaculture industry and had become an important environmental factor hindering the healthy and sustainable development of the abalone aquaculture industry. In this paper, research progress on the mechanism of response to hypoxia in abalone is reviewed from the perspectives of growth, survival, physiological and biochemical indexes (including, heart rate, metabolism, enzyme activity, pH, etc.), immune function as well as stress response genes and their expression regulation, with a view to providing a reference for further research on abalone's mechanism of response to hypoxia stress and developing new varieties of abalone resistant to hypoxia. In addition, the prevention and control measures of abalone hypoxia stress are also proposed, hoping to help farmers reduce the losses caused by the large-scale death of cultured abalone-caused hypoxic stress in summer.