基因编辑技术在贝类中的应用进展与展望
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Q 789;S 917.4

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国家重点研发计划 (2018YFD0900200);国家自然科学基金 (31672649)


Application advances and prospects of genome editing in molluscs
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    摘要:

    基因编辑是进行生物体遗传修饰的重要手段,已广泛应用于功能基因组学研究、动物模型制备、动植物遗传改良、基因治疗等多个研究领域。近年来CRISPR/Cas9技术的出现更是为生命科学领域带来一场技术革命,高效、精准、低成本的CRISPR技术已成为目前人们探究基因功能、解析生命现象的重要工具,在贝类中的应用也日益增多。本文就基因编辑技术的发展、作用原理及其在贝类中的应用进展进行综述,并对其未来发展进行了分析展望,以期推动该技术在贝类研究中得到更广泛的应用,为贝类基因功能解析、经济性状调控、基因挖掘、遗传改良等研究提供参考。

    Abstract:

    Genome editing is an important means of genetic modification of organisms. It has been widely used in a broad spectrum of fields, such as functional genomics, animal model generation, genetic improvement of animals and plants, and gene therapy. In recent years, the emergence of CRISPR/Cas9 technology has sparked a revolution in biological research. Efficient, accurate and low-cost CRISPR technology has become a useful tool to explore gene functions and elucidate life phenomena, and its application in molluscs is expanding rapidly. In this review, we introduced the developmental course and working mechanisms of gene editing technology, and its application and prospects in molluscs, which might promote further application of genome editing in more molluscan researches, and provide information for identification of gene functions, determining genes related to economic trait, and genetic improvement.

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YU Hong, LIU Xin, LI Qi. Application advances and prospects of genome editing in molluscs[J]. Journal of Fisheries of China,2022,46(4):636~643

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  • 收稿日期:2021-08-12
  • 最后修改日期:2021-09-15
  • 录用日期:2021-09-16
  • 在线发布日期: 2022-04-15
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