17β-HSDs的种类和功能概述及其在贝类中的研究进展
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S 917.4

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国家自然科学基金(31702314);福建省卫生健康中青年骨干人才培养项目(2019-ZQNB-21);福建省中青年教师教育科研项目(JT180661, JAT190849);海洋生物医药资源福建省高校工程研究中心(厦门医学院)开放课题(XMMC-MBS201901);天然化妆品福建省高校工程研究中心(厦门医学院)开放课题(XMMC-NC201901)


Review of types and functions of 17β-HSDs and related research progress in mollusks
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    摘要:

    为深入解析17β-HSDs (17β-羟基类固醇脱氢酶)对贝类性腺发育和生殖内分泌的调控机制,本文综述了17β-HSDs的种类和功能,对迄今已报道的所有亚型进行了分类归纳,并对贝类等水产动物中17β-HSDs的克隆表达、功能阐述、机制推测进行了调研总结。目前,虽然17β-HSDs调控贝类生殖过程研究已取得一定的进展,但仍有很多重要的科学问题尚待解答,需要重点加强“发现贝类中17β-HSDs新亚型、分析时空表达特征、解析构效关系、明晰环境污染物的影响、制定相应对策、指导产业实践应用”等方面的研究。本综述结合了其他物种的成熟研究和最新成果,为深入探究17β-HSDs调控贝类性腺发育和生殖内分泌的机理及应用提供了借鉴。

    Abstract:

    In order to understand the regulation mechanism of 17β-HSDs on gonadal development and reproductive endocrine of mollusks, this paper has reviewed the types and functions of 17β-HSDs, classified all the subtypes reported so far, and summarized the cloning, expression, function and mechanism of 17β-HSDs in mollusks. In spite of some progress made in 17β-HSDs regulating the reproductive process of mollusks, many underlying problems remain unsolved and further investigations are needed: ① discovering new subtypes of 17β-HSDs in mollusks; ② analyzing the temporal and spatial characteristics of expression; ③ investigating the structure-activity relationship; ④ clarifying the impact of environmental pollutants and making the corresponding countermeasures; ⑤ guiding the practice and application of aquaculture industry. This review has referred to former research on other species, which offers reference and guidance for further study on the mechanism and application of 17β-HSDs in regulating gonadal development and reproductive endocrine of mollusks.

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ZENG Zhen, YU Meishun, TAN Qianglai, SHI Bo, LI Jianbo, LI Weijie, CAI Guang. Review of types and functions of 17β-HSDs and related research progress in mollusks[J]. Journal of Fisheries of China,2022,46(6):1104~1116

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  • 收稿日期:2020-11-23
  • 最后修改日期:2021-04-18
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  • 在线发布日期: 2022-06-18
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