Effects of anthracene on activity of superoxide dismutase( SOD) in serum, liver, kidney , gill and muscle tissues of Sebastodes fuscescens were studied by toxic experimental methods. The results showed as follows: 1. SOD activities exhibited dif ferences among tested tissues, the order of SOD activity from high to low was liver > serum> kidney> gill> muscle. 2. The senstivity of SOD to anthracene also exhibited obvious differences among tested tissues, the most sensitive one to anthracene was serum SOD; the following were SOD of liver, gill and muscle tissues respectively ; the tolerance of kidney SOD to anthracene was the most strongest among them. 3. The changes of SOD act ivity under anthracene stress were different among tested tissuse, low levels of anthracene could stimulate SOD activity of gill, kidney and muscle t issues, while the SOD activity of serum and liver always showed inhibition from low to high anthracene concentrat ion.